INHIBITION BY ACETYLSALICYLIC ACID OF RICKETTSIAL STRAINS RESISTANT TO p -AMINOBENZOIC ACID
نویسندگان
چکیده
منابع مشابه
Inhibition by acetylsalicylic acid of rickettsial strains resistant to p-aminobenzoic acid.
Two p-aminobenzoic acid-resistant mutants of the Madrid E strain of Rickettsia prowazekii, pr and prr have been described in previous publications (Weiss et al., 1957; 1959). It has been shown that certain properties, such as antigenic specificity, infectivity, and virulence for the chick embryo and cotton rat, have not changed in these strains. However, when the study was extended to susceptib...
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p-Aminobenzoic acid (PABA) exerts three metabolic effects on E. coli: it acts as a normal vitamin at low concentrations, as a source of another vitamin, p-hydroxybenzoic acid (POB), at moderate concentrations, and as a growth inhibitor at high concentrations (150 to 1600 microg./ml.). The inhibition is competitively reversed by POB in 1/100 the concentration of PABA. The inhibition is also reve...
متن کاملMechanism of competitive inhibition of p-aminobenzoic acid oxidation by p-aminosalicylic acid.
The proposed mechanism(s) associated with the inhibition of essential metabolic reactions by various compounds has received a great deal of attention in recent years, since antimetabolites have proved useful in several chemotherapeutic areas and in studying various metabolic reactions. The significance of p-aminobenzoic acid in microbial nutrition was first emphasized when Woods (1940) and Wood...
متن کاملSeparation of p-Aminobenzoic Acid Derivatives
According to the literature, p-aminobenzoic acid (PAB) is excreted in the urine mostly as the free acid and its N-acetyl derivative; the remaining part is eliminated conjugated with glucuronic acid and as p-aminohippuric acid (PAH) (Ellinger & Hensel, 1914'; Hensel, 1914; Cohen & McGilvery, 1946; Salassa, Bollman & Dry, 1948). There is no agreement concerning the formation of PAH. Thus, Beyer, ...
متن کاملInhibition of Saccharomyces cerevisiae by p-aminobenzoic acid and its reversal by the aromatic amino acids.
It has been known for many years that p-aminobenzoic acid at high concentration is inhibitory to a variety of organisms, including rickettsiae (I), bacteria (2, 3), fungi (4), protozoa (5), and plants (6). The site of inhibition by p-aminobenzoic acid in most of these organisms has not been established. However, Davis (3) has shown that the bacteriostatic activity of p-aminobenzoic acid toward ...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1959
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.78.3.432-440.1959